Death after Eprinomectin + Praziquantel in cats

The FDA has received 30 reports of death in cats after Eprinomectin + Praziquantel. That is 5.1% of all reports for this medicine, compared with 8.9% across reports for all cat medicines, so it is reported less often than average with this medicine.

30Reports
100%Marked serious
0.0%Recovered
100%Died or euthanised
1 daysTypical onset
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How soon it started

Same day
13 45%
1–2 days
10 34%
3–7 days
3 10%
1–4 weeks
2 6.9%
Over a month
1 3.4%

How the animals did

Died
17 57%
Euthanised
13 43%

Problems reported at the same time

Seizures
9 30%
Breathing problems
7 23%
Eye or vision problems
5 17%
Lateral recumbency
5 17%
Disorientation
4 13%

Age of the animals

Under 1 year
6
1–3 years
8
4–7 years
3
8–11 years
4
12+ years
8

About this medicine

Eprinomectin controls worms and prevents heartworm. Praziquantel treats tapeworms.

Some herding breeds (for example Collies) carry the MDR1 gene variant and can be more sensitive to this drug class at high doses.

Questions owners ask

Can Eprinomectin + Praziquantel cause death in cats?
30 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 1 day of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Death with similar medicines

All reported side effects of Eprinomectin + Praziquantel in cats · Medicines most reported with death