Vomiting after Eprinomectin + Praziquantel in cats

The FDA has received 99 reports of vomiting in cats after Eprinomectin + Praziquantel. That is 17% of all reports for this medicine, compared with 18% across reports for all cat medicines.

99Reports
15%Marked serious
37%Recovered
6.1%Died or euthanised
Same dayTypical onset
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How soon it started

Same day
70 72%
1–2 days
21 22%
3–7 days
4 4.1%
1–4 weeks
1 1.0%
Over a month
1 1.0%

How the animals did

Recovered
37 37%
Still unwell when reported
8 8.1%
Died
6 6.1%
Not known
48 48%

Problems reported at the same time

26 26%
19 19%
14 14%
Vocalising
7 7.1%
Seizures
6 6.1%

Age of the animals

Under 1 year
32
1–3 years
28
4–7 years
7
8–11 years
8
12+ years
12

About this medicine

Eprinomectin controls worms and prevents heartworm. Praziquantel treats tapeworms.

Some herding breeds (for example Collies) carry the MDR1 gene variant and can be more sensitive to this drug class at high doses.

Questions owners ask

Can Eprinomectin + Praziquantel cause vomiting in cats?
99 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within the same day of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Vomiting with similar medicines

All reported side effects of Eprinomectin + Praziquantel in cats · Medicines most reported with vomiting