Loss of appetite after Eprinomectin + Praziquantel in cats

The FDA has received 62 reports of loss of appetite in cats after Eprinomectin + Praziquantel. That is 11% of all reports for this medicine, compared with 14% across reports for all cat medicines.

62Reports
26%Marked serious
24%Recovered
3.2%Died or euthanised
1 daysTypical onset
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How soon it started

Same day
23 38%
1–2 days
30 49%
3–7 days
6 9.8%
1–4 weeks
2 3.3%
Over a month
0 0.0%

How the animals did

Recovered
15 24%
Still unwell when reported
8 13%
Died
1 1.6%
Euthanised
1 1.6%
Not known
37 60%

Problems reported at the same time

43 69%
17 27%
Not drinking
10 16%
Fever
8 13%
Liver problems
8 13%
Blood problems
7 11%

Age of the animals

Under 1 year
20
1–3 years
15
4–7 years
12
8–11 years
3
12+ years
8

About this medicine

Eprinomectin controls worms and prevents heartworm. Praziquantel treats tapeworms.

Some herding breeds (for example Collies) carry the MDR1 gene variant and can be more sensitive to this drug class at high doses.

Questions owners ask

Can Eprinomectin + Praziquantel cause loss of appetite in cats?
62 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 1 day of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Loss of appetite with similar medicines

All reported side effects of Eprinomectin + Praziquantel in cats · Medicines most reported with loss of appetite