Death after Selamectin (Revolution) in cats

1,260 reports to the FDA describe death in cats given Selamectin. That is 5.7% of all reports for this medicine, compared with 8.9% across reports for all cat medicines, so it is reported less often than average with this medicine.

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How soon it started

How the animals did

Problems reported at the same time

Age of the animals

About this medicine

Selamectin prevents heartworm and treats fleas, ear mites and some worms (spot-on).

Products with this ingredient include Revolution. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Some herding breeds (for example Collies) carry the MDR1 gene variant and can be more sensitive to this drug class at high doses.

Questions owners ask

Can Selamectin cause death in cats?

1,260 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.

How soon after a dose was it reported?

In half of the reports with dates, it started within 1 day of the first dose.

What should I do?

Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Death with similar medicines

• Death after Eprinomectin + Esafoxolaner + Praziquantel (NexGard Combo) 244 reports · 7.5% of its reports
• Death after Ivermectin (Heartgard) 100 reports · 10% of its reports
• Death after Eprinomectin + Praziquantel 30 reports · 5.1% of its reports
• Death after Milbemycin Oxime (Interceptor) 20 reports · 4.9% of its reports

All reported side effects of Selamectin in cats · Medicines most reported with death