Wobbliness (ataxia) after Selamectin (Revolution) in cats

The FDA has received 812 reports of wobbliness (ataxia) in cats after Selamectin. That is 3.7% of all reports for this medicine, compared with 4.7% across reports for all cat medicines.

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How soon it started

How the animals did

Problems reported at the same time

Age of the animals

About this medicine

Selamectin prevents heartworm and treats fleas, ear mites and some worms (spot-on).

Products with this ingredient include Revolution. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Some herding breeds (for example Collies) carry the MDR1 gene variant and can be more sensitive to this drug class at high doses.

Questions owners ask

Can Selamectin cause wobbliness (ataxia) in cats?

812 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.

How soon after a dose was it reported?

In half of the reports with dates, it started within 1 day of the first dose.

What should I do?

Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Wobbliness (ataxia) with similar medicines

• Wobbliness (ataxia) after Eprinomectin + Esafoxolaner + Praziquantel (NexGard Combo) 224 reports · 6.9% of its reports
• Wobbliness (ataxia) after Ivermectin (Heartgard) 227 reports · 24% of its reports
• Wobbliness (ataxia) after Eprinomectin + Praziquantel 29 reports · 5.0% of its reports
• Wobbliness (ataxia) after Milbemycin Oxime (Interceptor) 54 reports · 13% of its reports
• Wobbliness (ataxia) after Milbemycin Oxime + Spinosad (Trifexis) 25 reports · 8.3% of its reports

All reported side effects of Selamectin in cats · Medicines most reported with wobbliness (ataxia)