Drooling after Selamectin (Revolution) in cats

641 reports to the FDA describe drooling in cats given Selamectin. That is 2.9% of all reports for this medicine, compared with 5.6% across reports for all cat medicines, so it is reported less often than average with this medicine.

641Reports
12%Marked serious
10%Recovered
11%Died or euthanised
Same dayTypical onset
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How soon it started

Same day
150 59%
1–2 days
61 24%
3–7 days
21 8.3%
1–4 weeks
8 3.1%
Over a month
14 5.5%

How the animals did

Recovered
65 10%
Still unwell when reported
101 16%
Died
53 8.3%
Euthanised
19 3.0%
Not known
403 63%

Problems reported at the same time

Age of the animals

Under 1 year
142
1–3 years
173
4–7 years
139
8–11 years
74
12+ years
57

About this medicine

Selamectin prevents heartworm and treats fleas, ear mites and some worms (spot-on).

Products with this ingredient include Revolution. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Some herding breeds (for example Collies) carry the MDR1 gene variant and can be more sensitive to this drug class at high doses.

Questions owners ask

Can Selamectin cause drooling in cats?
641 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within the same day of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Drooling with similar medicines

All reported side effects of Selamectin in cats · Medicines most reported with drooling