Lethargy after Selamectin (Revolution) in cats

The FDA has received 3,126 reports of lethargy in cats after Selamectin. That is 14% of all reports for this medicine, compared with 14% across reports for all cat medicines.

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How soon it started

How the animals did

Problems reported at the same time

Age of the animals

About this medicine

Selamectin prevents heartworm and treats fleas, ear mites and some worms (spot-on).

Products with this ingredient include Revolution. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Some herding breeds (for example Collies) carry the MDR1 gene variant and can be more sensitive to this drug class at high doses.

Questions owners ask

Can Selamectin cause lethargy in cats?

3,126 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.

How soon after a dose was it reported?

In half of the reports with dates, it started within 1 day of the first dose.

What should I do?

Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Lethargy with similar medicines

• Lethargy after Eprinomectin + Esafoxolaner + Praziquantel (NexGard Combo) 533 reports · 16% of its reports
• Lethargy after Ivermectin (Heartgard) 178 reports · 18% of its reports
• Lethargy after Eprinomectin + Praziquantel 96 reports · 16% of its reports
• Lethargy after Milbemycin Oxime (Interceptor) 79 reports · 20% of its reports
• Lethargy after Milbemycin Oxime + Spinosad (Trifexis) 91 reports · 30% of its reports

All reported side effects of Selamectin in cats · Medicines most reported with lethargy