Lethargy after Eprinomectin + Esafoxolaner + Praziquantel (NexGard Combo) in cats
533 reports to the FDA describe lethargy in cats given Eprinomectin + Esafoxolaner + Praziquantel. That is 16% of all reports for this medicine, compared with 14% across reports for all cat medicines.
How soon it started
How the animals did
Problems reported at the same time
Age of the animals
About this medicine
Eprinomectin controls worms and prevents heartworm. Esafoxolaner kills fleas and ticks (spot-on for cats). Praziquantel treats tapeworms.
Products with this combination include NexGard Combo. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.
Some herding breeds (for example Collies) carry the MDR1 gene variant and can be more sensitive to this drug class at high doses.
Questions owners ask
- Can Eprinomectin + Esafoxolaner + Praziquantel cause lethargy in cats?
- 533 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
- How soon after a dose was it reported?
- In half of the reports with dates, it started within the same day of the first dose.
- What should I do?
- Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).
Lethargy with similar medicines
- Lethargy after Selamectin (Revolution) 3,126 reports · 14% of its reports
- Lethargy after Ivermectin (Heartgard) 178 reports · 18% of its reports
- Lethargy after Eprinomectin + Praziquantel 96 reports · 16% of its reports
- Lethargy after Milbemycin Oxime (Interceptor) 79 reports · 20% of its reports
- Lethargy after Milbemycin Oxime + Spinosad (Trifexis) 91 reports · 30% of its reports
All reported side effects of Eprinomectin + Esafoxolaner + Praziquantel in cats · Medicines most reported with lethargy