Eprinomectin + Esafoxolaner + Praziquantel (NexGard Combo) side effects in cats
3,247 reports sent to the FDA between 2023 and 2026 involve Eprinomectin + Esafoxolaner + Praziquantel in cats. The most reported problems were lethargy, drooling, loss of appetite. 15% were marked serious.
About this medicine
Eprinomectin controls worms and prevents heartworm. Esafoxolaner kills fleas and ticks (spot-on for cats). Praziquantel treats tapeworms.
Products with this combination include NexGard Combo. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.
Some herding breeds (for example Collies) carry the MDR1 gene variant and can be more sensitive to this drug class at high doses.
Most reported side effects
Share = percentage of this medicine's reports that mention the problem. One report can list several problems.
Reports that it didn't work
Some reports are about the medicine not working (for example a cat still getting fleas or heartworm), not about a side effect.
How soon problems started
Time from the first dose to the first sign, where both dates were reported (3,168 reports).
How the animals did
Breeds named most often
Popular breeds appear more often because there are more of them.
- Domestic Shorthair 1,968 reports
- Domestic Longhair 230 reports
- Domestic Mediumhair 197 reports
- Siamese 35 reports
- Maine Coon 34 reports
- Ragdoll 29 reports
- American Shorthair 18 reports
- Persian 16 reports
- Russian 14 reports
- Bengal 13 reports