Accidental exposure after Eprinomectin + Esafoxolaner + Praziquantel (NexGard Combo) in cats

153 reports to the FDA describe accidental exposure in cats given Eprinomectin + Esafoxolaner + Praziquantel. That is 4.7% of all reports for this medicine, compared with 2.6% across reports for all cat medicines, so it is reported unusually often with this medicine.

153Reports

5.2%Marked serious

36%Recovered

2.6%Died or euthanised

Same dayTypical onset

How soon it started

Same day

135 91%

1–2 days

7 4.7%

3–7 days

4 2.7%

1–4 weeks

2 1.3%

Over a month

1 0.7%

How the animals did

Recovered

55 36%

Still unwell when reported

4 2.6%

Died

2 1.3%

Euthanised

2 1.3%

Not known

90 59%

Problems reported at the same time

Drooling

74 48%

Incorrect route of drug administration

50 33%

Application site reaction

49 32%

45 29%

26 17%

10 6.5%

10 6.5%

9 5.9%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Eprinomectin controls worms and prevents heartworm. Esafoxolaner kills fleas and ticks (spot-on for cats). Praziquantel treats tapeworms.

Products with this combination include NexGard Combo. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Some herding breeds (for example Collies) carry the MDR1 gene variant and can be more sensitive to this drug class at high doses.

Questions owners ask

Can Eprinomectin + Esafoxolaner + Praziquantel cause accidental exposure in cats?: 153 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within the same day of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Accidental exposure with similar medicines

Accidental exposure after Selamectin (Revolution) 352 reports · 1.6% of its reports
Accidental exposure after Ivermectin (Heartgard) 53 reports · 5.5% of its reports
Accidental exposure after Milbemycin Oxime (Interceptor) 36 reports · 8.9% of its reports
Accidental exposure after Milbemycin Oxime + Spinosad (Trifexis) 96 reports · 32% of its reports
Accidental exposure after Ivermectin + Pyrantel (Heartgard Plus) 37 reports · 56% of its reports

All reported side effects of Eprinomectin + Esafoxolaner + Praziquantel in cats · Medicines most reported with accidental exposure