Accidental exposure after Ivermectin + Pyrantel (Heartgard Plus) in cats
37 reports to the FDA describe accidental exposure in cats given Ivermectin + Pyrantel. That is 56% of all reports for this medicine, compared with 2.6% across reports for all cat medicines, so it is reported unusually often with this medicine.
How the animals did
Problems reported at the same time
Age of the animals
About this medicine
Ivermectin prevents heartworm disease (monthly). Pyrantel treats roundworms and hookworms.
Products with this combination include Heartgard Plus, Tri-Heart Plus, Iverhart Plus. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.
Some herding breeds (for example Collies) carry the MDR1 gene variant and can be more sensitive to this drug class at high doses.
Questions owners ask
- Can Ivermectin + Pyrantel cause accidental exposure in cats?
- 37 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
- What should I do?
- Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).
Accidental exposure with similar medicines
- Accidental exposure after Selamectin (Revolution) 352 reports · 1.6% of its reports
- Accidental exposure after Eprinomectin + Esafoxolaner + Praziquantel (NexGard Combo) 153 reports · 4.7% of its reports
- Accidental exposure after Ivermectin (Heartgard) 53 reports · 5.5% of its reports
- Accidental exposure after Milbemycin Oxime (Interceptor) 36 reports · 8.9% of its reports
- Accidental exposure after Milbemycin Oxime + Spinosad (Trifexis) 96 reports · 32% of its reports
All reported side effects of Ivermectin + Pyrantel in cats · Medicines most reported with accidental exposure