Application site reaction after Eprinomectin + Esafoxolaner + Praziquantel (NexGard Combo) in cats
The FDA has received 416 reports of application site reaction in cats after Eprinomectin + Esafoxolaner + Praziquantel. That is 13% of all reports for this medicine, compared with 8.1% across reports for all cat medicines, so it is reported unusually often with this medicine.
How soon it started
How the animals did
Problems reported at the same time
Age of the animals
About this medicine
Eprinomectin controls worms and prevents heartworm. Esafoxolaner kills fleas and ticks (spot-on for cats). Praziquantel treats tapeworms.
Products with this combination include NexGard Combo. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.
Some herding breeds (for example Collies) carry the MDR1 gene variant and can be more sensitive to this drug class at high doses.
Questions owners ask
- Can Eprinomectin + Esafoxolaner + Praziquantel cause application site reaction in cats?
- 416 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
- How soon after a dose was it reported?
- In half of the reports with dates, it started within 1 day of the first dose.
- What should I do?
- Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).
Application site reaction with similar medicines
- Application site reaction after Selamectin (Revolution) 4,198 reports · 19% of its reports
- Application site reaction after Eprinomectin + Praziquantel 66 reports · 11% of its reports
All reported side effects of Eprinomectin + Esafoxolaner + Praziquantel in cats · Medicines most reported with application site reaction