Application site reaction after Eprinomectin + Praziquantel in cats

66 reports to the FDA describe application site reaction in cats given Eprinomectin + Praziquantel. That is 11% of all reports for this medicine, compared with 8.1% across reports for all cat medicines.

66Reports
1.5%Marked serious
18%Recovered
0.0%Died or euthanised
1 daysTypical onset
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How soon it started

Same day
24 36%
1–2 days
22 33%
3–7 days
12 18%
1–4 weeks
8 12%
Over a month
0 0.0%

How the animals did

Recovered
12 18%
Still unwell when reported
4 6.1%
Not known
50 76%

Problems reported at the same time

Hair loss
24 36%
Drooling
11 17%
Itching
10 15%
Accidental exposure
8 12%
Vomiting
4 6.1%
Restlessness or agitation
4 6.1%
Foaming at the mouth
3 4.5%
Lethargy
3 4.5%

Age of the animals

Under 1 year
9
1–3 years
14
4–7 years
15
8–11 years
14
12+ years
4

About this medicine

Eprinomectin controls worms and prevents heartworm. Praziquantel treats tapeworms.

Some herding breeds (for example Collies) carry the MDR1 gene variant and can be more sensitive to this drug class at high doses.

Questions owners ask

Can Eprinomectin + Praziquantel cause application site reaction in cats?
66 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 1 day of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Application site reaction with similar medicines

All reported side effects of Eprinomectin + Praziquantel in cats · Medicines most reported with application site reaction