Ivermectin (Heartgard) side effects in cats

965 reports sent to the FDA between 1995 and 2026 involve Ivermectin in cats. The most reported problems were vomiting, wobbliness (ataxia), lethargy. 20% were marked serious, and where it was recorded, signs eased after stopping the medicine in 0% of cases.

965Reports
20%Marked serious
84%Only medicine involved
19%Recovered
11%Died or euthanised
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About this medicine

Ivermectin prevents heartworm disease (monthly).

Products with this ingredient include Heartgard. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Some herding breeds (for example Collies) carry the MDR1 gene variant and can be more sensitive to this drug class at high doses.

Most reported side effects

Share = percentage of this medicine's reports that mention the problem. One report can list several problems.

Reports that it didn't work

Some reports are about the medicine not working (for example a cat still getting fleas or heartworm), not about a side effect.

Didn't stop worms
11 1.1%
Didn't work as expected
10 1.0%
Didn't stop fleas
1 0.1%

How soon problems started

Same day
96 39%
1–2 days
53 22%
3–7 days
13 5.3%
1–4 weeks
27 11%
Over a month
57 23%

Time from the first dose to the first sign, where both dates were reported (246 reports).

How the animals did

Recovered
174 18%
Recovered with lasting effects
14 1.5%
Still unwell when reported
25 2.6%
Died
98 10%
Euthanised
6 0.6%
Not known
648 67%

Breeds named most often

Popular breeds appear more often because there are more of them.

Other macrocyclic lactone (heartworm and parasite prevention)s for cats