Hiding after Eprinomectin + Esafoxolaner + Praziquantel (NexGard Combo) in cats

132 reports to the FDA describe hiding in cats given Eprinomectin + Esafoxolaner + Praziquantel. That is 4.1% of all reports for this medicine, compared with 2.4% across reports for all cat medicines, so it is reported unusually often with this medicine.

132Reports
21%Marked serious
32%Recovered
11%Died or euthanised
Same dayTypical onset
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How soon it started

Same day
77 58%
1–2 days
31 23%
3–7 days
12 9.1%
1–4 weeks
10 7.6%
Over a month
2 1.5%

How the animals did

Recovered
41 31%
Recovered with lasting effects
1 0.8%
Still unwell when reported
12 9.1%
Died
8 6.1%
Euthanised
7 5.3%
Not known
63 48%

Problems reported at the same time

Age of the animals

Under 1 year
17
1–3 years
45
4–7 years
32
8–11 years
17
12+ years
18

About this medicine

Eprinomectin controls worms and prevents heartworm. Esafoxolaner kills fleas and ticks (spot-on for cats). Praziquantel treats tapeworms.

Products with this combination include NexGard Combo. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Some herding breeds (for example Collies) carry the MDR1 gene variant and can be more sensitive to this drug class at high doses.

Questions owners ask

Can Eprinomectin + Esafoxolaner + Praziquantel cause hiding in cats?
132 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within the same day of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Hiding with similar medicines

All reported side effects of Eprinomectin + Esafoxolaner + Praziquantel in cats · Medicines most reported with hiding