Wobbliness (ataxia) after Eprinomectin + Praziquantel in cats

29 reports to the FDA describe wobbliness (ataxia) in cats given Eprinomectin + Praziquantel. That is 5.0% of all reports for this medicine, compared with 4.7% across reports for all cat medicines.

29Reports
38%Marked serious
34%Recovered
31%Died or euthanised
1 daysTypical onset
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How soon it started

Same day
13 48%
1–2 days
13 48%
3–7 days
1 3.7%
1–4 weeks
0 0.0%
Over a month
0 0.0%

How the animals did

Recovered
10 34%
Still unwell when reported
1 3.4%
Died
5 17%
Euthanised
4 14%
Not known
9 31%

Problems reported at the same time

9 31%
Disorientation
9 31%
8 28%
Seizures
6 21%
Eye or vision problems
5 17%

Age of the animals

Under 1 year
7
1–3 years
14
4–7 years
2
8–11 years
2
12+ years
4

About this medicine

Eprinomectin controls worms and prevents heartworm. Praziquantel treats tapeworms.

Some herding breeds (for example Collies) carry the MDR1 gene variant and can be more sensitive to this drug class at high doses.

Questions owners ask

Can Eprinomectin + Praziquantel cause wobbliness (ataxia) in cats?
29 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 1 day of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Wobbliness (ataxia) with similar medicines

All reported side effects of Eprinomectin + Praziquantel in cats · Medicines most reported with wobbliness (ataxia)