Disorientation after Emodepside + Praziquantel (Profender) in cats

The FDA has received 46 reports of disorientation in cats after Emodepside + Praziquantel. That is 0.8% of all reports for this medicine, compared with 1.0% across reports for all cat medicines.

46Reports

48%Marked serious

30%Recovered

8.7%Died or euthanised

Same dayTypical onset

How soon it started

Same day

25 78%

1–2 days

4 13%

3–7 days

1 3.1%

1–4 weeks

2 6.3%

Over a month

0 0.0%

How the animals did

Recovered

14 30%

Still unwell when reported

5 11%

Died

2 4.3%

Euthanised

2 4.3%

Not known

23 50%

Problems reported at the same time

23 50%

11 24%

11 24%

10 22%

10 22%

Restlessness or agitation

6 13%

Hyperglycaemia

5 11%

Vocalising

5 11%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Emodepside treats intestinal worms (spot-on for cats). Praziquantel treats tapeworms.

Products with this combination include Profender. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Emodepside + Praziquantel cause disorientation in cats?: 46 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within the same day of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Disorientation with similar medicines

Disorientation after Praziquantel + Pyrantel 25 reports · 2.0% of its reports

All reported side effects of Emodepside + Praziquantel in cats · Medicines most reported with disorientation