Breathing problems after Emodepside + Praziquantel (Profender) in cats

The FDA has received 163 reports of breathing problems in cats after Emodepside + Praziquantel. That is 2.8% of all reports for this medicine, compared with 4.7% across reports for all cat medicines, so it is reported less often than average with this medicine.

163Reports
77%Marked serious
37%Recovered
25%Died or euthanised
Same dayTypical onset
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How soon it started

Same day
82 59%
1–2 days
30 22%
3–7 days
13 9.4%
1–4 weeks
10 7.2%
Over a month
3 2.2%

How the animals did

Recovered
60 37%
Still unwell when reported
14 8.6%
Died
25 15%
Euthanised
16 9.8%
Not known
48 29%

Problems reported at the same time

Age of the animals

Under 1 year
24
1–3 years
47
4–7 years
51
8–11 years
20
12+ years
16

About this medicine

Emodepside treats intestinal worms (spot-on for cats). Praziquantel treats tapeworms.

Products with this combination include Profender. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Emodepside + Praziquantel cause breathing problems in cats?
163 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within the same day of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Breathing problems with similar medicines

All reported side effects of Emodepside + Praziquantel in cats · Medicines most reported with breathing problems