Lethargy after Vincristine in dogs

22 reports to the FDA describe lethargy in dogs given Vincristine. That is 42% of all reports for this medicine, compared with 11% across reports for all dog medicines, so it is reported unusually often with this medicine.

22Reports
95%Marked serious
4.5%Recovered
59%Died or euthanised
17 daysTypical onset
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How soon it started

Same day
2 13%
1–2 days
0 0.0%
3–7 days
4 25%
1–4 weeks
7 44%
Over a month
3 19%

How the animals did

Recovered
1 4.5%
Still unwell when reported
6 27%
Died
5 23%
Euthanised
8 36%
Not known
2 9.1%

Problems reported at the same time

13 59%
12 55%
Liver problems
11 50%
Leucocytosis
10 45%
Diarrhea
7 32%
Neutrophilia
5 23%

Age of the animals

Under 1 year
0
1–3 years
1
4–7 years
10
8–11 years
9
12+ years
2

About this medicine

Type: medicine.

Questions owners ask

Can Vincristine cause lethargy in dogs?
22 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 17 days of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Lethargy with similar medicines

All reported side effects of Vincristine in dogs · Medicines most reported with lethargy