Pale mucous membrane after Trilostane (Vetoryl) in dogs

The FDA has received 58 reports of pale mucous membrane in dogs after Trilostane. That is 0.5% of all reports for this medicine, compared with 0.7% across reports for all dog medicines, so it is reported less often than average with this medicine.

58Reports
84%Marked serious
3.4%Recovered
34%Died or euthanised
54 daysTypical onset
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How soon it started

Same day
3 6.7%
1–2 days
4 8.9%
3–7 days
2 4.4%
1–4 weeks
6 13%
Over a month
30 67%

How the animals did

Recovered
2 3.4%
Still unwell when reported
16 28%
Died
7 12%
Euthanised
13 22%
Not known
20 34%

Problems reported at the same time

Age of the animals

Under 1 year
0
1–3 years
0
4–7 years
4
8–11 years
29
12+ years
25

About this medicine

Trilostane treats Cushing's disease (an overactive adrenal gland).

Products with this ingredient include Vetoryl. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Trilostane cause pale mucous membrane in dogs?
58 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 54 days of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Pale mucous membrane with similar medicines

All reported side effects of Trilostane in dogs · Medicines most reported with pale mucous membrane