Not drinking after Trilostane (Vetoryl) in dogs

The FDA has received 105 reports of not drinking in dogs after Trilostane. That is 0.9% of all reports for this medicine, compared with 0.5% across reports for all dog medicines, so it is reported unusually often with this medicine.

105Reports

73%Marked serious

18%Recovered

37%Died or euthanised

18 daysTypical onset

How soon it started

Same day

10 11%

1–2 days

9 10%

3–7 days

11 13%

1–4 weeks

22 25%

Over a month

36 41%

How the animals did

Recovered

19 18%

Still unwell when reported

12 11%

Died

9 8.6%

Euthanised

30 29%

Not known

35 33%

Problems reported at the same time

97 92%

61 58%

45 43%

40 38%

26 25%

26 25%

24 23%

23 22%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Trilostane treats Cushing's disease (an overactive adrenal gland).

Products with this ingredient include Vetoryl. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Trilostane cause not drinking in dogs?: 105 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 18 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Not drinking with similar medicines

Not drinking after Insulin 24 reports · 0.3% of its reports
Not drinking after Phenylpropanolamine (Proin) 26 reports · 0.6% of its reports

All reported side effects of Trilostane in dogs · Medicines most reported with not drinking