Inappropriate schedule of drug administration after Trilostane (Vetoryl) in dogs

The FDA has received 81 reports of inappropriate schedule of drug administration in dogs after Trilostane. That is 0.7% of all reports for this medicine, compared with 0.1% across reports for all dog medicines, so it is reported unusually often with this medicine.

81Reports

38%Marked serious

17%Recovered

7.4%Died or euthanised

35 daysTypical onset

How soon it started

Same day

3 5.0%

1–2 days

1 1.7%

3–7 days

7 12%

1–4 weeks

16 27%

Over a month

33 55%

How the animals did

Recovered

14 17%

Still unwell when reported

5 6.2%

Died

4 4.9%

Euthanised

2 2.5%

Not known

56 69%

Problems reported at the same time

Underdose

31 38%

Didn't work as expected

24 30%

19 23%

18 22%

15 19%

15 19%

11 14%

10 12%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Trilostane treats Cushing's disease (an overactive adrenal gland).

Products with this ingredient include Vetoryl. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Trilostane cause inappropriate schedule of drug administration in dogs?: 81 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 35 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

All reported side effects of Trilostane in dogs · Medicines most reported with inappropriate schedule of drug administration