Hyperproteinaemia after Trilostane (Vetoryl) in dogs

88 reports to the FDA describe hyperproteinaemia in dogs given Trilostane. That is 0.7% of all reports for this medicine, compared with 0.2% across reports for all dog medicines, so it is reported unusually often with this medicine.

88Reports

73%Marked serious

1.1%Recovered

27%Died or euthanised

29 daysTypical onset

How soon it started

Same day

2 3.1%

1–2 days

5 7.8%

3–7 days

7 11%

1–4 weeks

19 30%

Over a month

31 48%

How the animals did

Recovered with lasting effects

1 1.1%

Still unwell when reported

19 22%

Died

3 3.4%

Euthanised

21 24%

Not known

44 50%

Problems reported at the same time

67 76%

39 44%

29 33%

29 33%

26 30%

26 30%

25 28%

25 28%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Trilostane treats Cushing's disease (an overactive adrenal gland).

Products with this ingredient include Vetoryl. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Trilostane cause hyperproteinaemia in dogs?: 88 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 29 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

All reported side effects of Trilostane in dogs · Medicines most reported with hyperproteinaemia