Elevated globulins after Trilostane (Vetoryl) in dogs

66 reports to the FDA describe elevated globulins in dogs given Trilostane. That is 0.6% of all reports for this medicine, compared with 0.2% across reports for all dog medicines, so it is reported unusually often with this medicine.

66Reports

61%Marked serious

1.5%Recovered

15%Died or euthanised

31 daysTypical onset

How soon it started

Same day

0 0.0%

1–2 days

1 2.1%

3–7 days

6 13%

1–4 weeks

16 34%

Over a month

24 51%

How the animals did

Recovered

1 1.5%

Still unwell when reported

11 17%

Euthanised

10 15%

Not known

44 67%

Problems reported at the same time

48 73%

33 50%

25 38%

23 35%

20 30%

19 29%

17 26%

17 26%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Trilostane treats Cushing's disease (an overactive adrenal gland).

Products with this ingredient include Vetoryl. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Trilostane cause elevated globulins in dogs?: 66 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 31 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

All reported side effects of Trilostane in dogs · Medicines most reported with elevated globulins