Hyperphosphataemia after Trilostane (Vetoryl) in dogs

373 reports to the FDA describe hyperphosphataemia in dogs given Trilostane. That is 3.1% of all reports for this medicine, compared with 0.6% across reports for all dog medicines, so it is reported unusually often with this medicine.

373Reports
74%Marked serious
2.9%Recovered
30%Died or euthanised
42 daysTypical onset
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How soon it started

Same day
9 3.1%
1–2 days
13 4.5%
3–7 days
31 11%
1–4 weeks
73 25%
Over a month
165 57%

How the animals did

Recovered
11 2.9%
Still unwell when reported
55 15%
Died
37 9.9%
Euthanised
75 20%
Not known
195 52%

Problems reported at the same time

Age of the animals

Under 1 year
1
1–3 years
0
4–7 years
26
8–11 years
162
12+ years
181

About this medicine

Trilostane treats Cushing's disease (an overactive adrenal gland).

Products with this ingredient include Vetoryl. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Trilostane cause hyperphosphataemia in dogs?
373 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 42 days of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Hyperphosphataemia with similar medicines

All reported side effects of Trilostane in dogs · Medicines most reported with hyperphosphataemia