High blood pressure after Trilostane (Vetoryl) in dogs

The FDA has received 53 reports of high blood pressure in dogs after Trilostane. That is 0.4% of all reports for this medicine, compared with 0.0% across reports for all dog medicines, so it is reported unusually often with this medicine.

53Reports

79%Marked serious

3.8%Recovered

11%Died or euthanised

47 daysTypical onset

How soon it started

Same day

1 2.3%

1–2 days

3 7.0%

3–7 days

3 7.0%

1–4 weeks

10 23%

Over a month

26 60%

How the animals did

Recovered

1 1.9%

Recovered with lasting effects

1 1.9%

Still unwell when reported

19 36%

Died

2 3.8%

Euthanised

4 7.5%

Not known

26 49%

Problems reported at the same time

Proteinuria

22 42%

Kidney problems

22 42%

Liver problems

19 36%

Decreased urine concentration

15 28%

12 23%

10 19%

10 19%

9 17%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Trilostane treats Cushing's disease (an overactive adrenal gland).

Products with this ingredient include Vetoryl. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Trilostane cause high blood pressure in dogs?: 53 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 47 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

High blood pressure with similar medicines

High blood pressure after Phenylpropanolamine (Proin) 44 reports · 1.1% of its reports

All reported side effects of Trilostane in dogs · Medicines most reported with high blood pressure