Diabetic ketonuria after Trilostane (Vetoryl) in dogs

The FDA has received 52 reports of diabetic ketonuria in dogs after Trilostane. That is 0.4% of all reports for this medicine, compared with 0.0% across reports for all dog medicines, so it is reported unusually often with this medicine.

52Reports

88%Marked serious

1.9%Recovered

23%Died or euthanised

31 daysTypical onset

How soon it started

Same day

1 2.4%

1–2 days

3 7.3%

3–7 days

3 7.3%

1–4 weeks

13 32%

Over a month

21 51%

How the animals did

Recovered

1 1.9%

Still unwell when reported

26 50%

Died

3 5.8%

Euthanised

9 17%

Not known

13 25%

Problems reported at the same time

34 65%

26 50%

23 44%

22 42%

22 42%

19 37%

19 37%

19 37%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Trilostane treats Cushing's disease (an overactive adrenal gland).

Products with this ingredient include Vetoryl. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Trilostane cause diabetic ketonuria in dogs?: 52 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 31 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Diabetic ketonuria with similar medicines

Diabetic ketonuria after Insulin 78 reports · 1.1% of its reports

All reported side effects of Trilostane in dogs · Medicines most reported with diabetic ketonuria