Diabetic ketonuria after Insulin in dogs

The FDA has received 78 reports of diabetic ketonuria in dogs after Insulin. That is 1.1% of all reports for this medicine, compared with 0.0% across reports for all dog medicines, so it is reported unusually often with this medicine.

78Reports

74%Marked serious

26%Recovered

22%Died or euthanised

32 daysTypical onset

How soon it started

Same day

3 6.5%

1–2 days

4 8.7%

3–7 days

8 17%

1–4 weeks

7 15%

Over a month

24 52%

How the animals did

Recovered

16 21%

Recovered with lasting effects

4 5.1%

Still unwell when reported

19 24%

Died

7 9.0%

Euthanised

10 13%

Not known

22 28%

Problems reported at the same time

Lethargy

37 47%

Hyperglycaemia

37 47%

Vomiting

37 47%

Didn't work as expected

36 46%

34 44%

21 27%

21 27%

18 23%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Insulin treats diabetes.

Questions owners ask

Can Insulin cause diabetic ketonuria in dogs?: 78 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 32 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Diabetic ketonuria with similar medicines

Diabetic ketonuria after Trilostane (Vetoryl) 52 reports · 0.4% of its reports

All reported side effects of Insulin in dogs · Medicines most reported with diabetic ketonuria