Diabetes after Trilostane (Vetoryl) in dogs

The FDA has received 119 reports of diabetes in dogs after Trilostane. That is 1.0% of all reports for this medicine, compared with 0.1% across reports for all dog medicines, so it is reported unusually often with this medicine.

119Reports

95%Marked serious

2.5%Recovered

21%Died or euthanised

37 daysTypical onset

How soon it started

Same day

2 2.1%

1–2 days

5 5.3%

3–7 days

9 9.6%

1–4 weeks

24 26%

Over a month

54 57%

How the animals did

Recovered with lasting effects

3 2.5%

Still unwell when reported

60 50%

Died

4 3.4%

Euthanised

21 18%

Not known

31 26%

Problems reported at the same time

48 40%

38 32%

38 32%

37 31%

32 27%

27 23%

25 21%

21 18%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Trilostane treats Cushing's disease (an overactive adrenal gland).

Products with this ingredient include Vetoryl. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Trilostane cause diabetes in dogs?: 119 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 37 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Diabetes with similar medicines

Diabetes after Insulin 63 reports · 0.9% of its reports

All reported side effects of Trilostane in dogs · Medicines most reported with diabetes