Dermal thickening after Trilostane (Vetoryl) in dogs

20 reports to the FDA describe dermal thickening in dogs given Trilostane. That is 0.2% of all reports for this medicine, compared with 0.0% across reports for all dog medicines, so it is reported unusually often with this medicine.

20Reports
85%Marked serious
0.0%Recovered
10%Died or euthanised
171 daysTypical onset
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How soon it started

Same day
0 0.0%
1–2 days
2 12%
3–7 days
2 12%
1–4 weeks
0 0.0%
Over a month
13 76%

How the animals did

Still unwell when reported
10 50%
Died
1 5.0%
Euthanised
1 5.0%
Not known
8 40%

Problems reported at the same time

Hair loss
10 50%
Lethargy
7 35%
Liver problems
7 35%
Weight loss
6 30%
Cutaneous calcinosis
6 30%
Skin redness
6 30%
Loss of appetite
5 25%
Proteinuria
4 20%

Age of the animals

Under 1 year
0
1–3 years
0
4–7 years
4
8–11 years
10
12+ years
6

About this medicine

Trilostane treats Cushing's disease (an overactive adrenal gland).

Products with this ingredient include Vetoryl. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Trilostane cause dermal thickening in dogs?
20 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 171 days of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

All reported side effects of Trilostane in dogs · Medicines most reported with dermal thickening