Cardiac disorder after Trilostane (Vetoryl) in dogs

29 reports to the FDA describe cardiac disorder in dogs given Trilostane. That is 0.2% of all reports for this medicine, compared with 1.1% across reports for all dog medicines, so it is reported less often than average with this medicine.

29Reports

90%Marked serious

0.0%Recovered

28%Died or euthanised

91 daysTypical onset

How soon it started

Same day

0 0.0%

1–2 days

1 5.9%

3–7 days

0 0.0%

1–4 weeks

2 12%

Over a month

14 82%

How the animals did

Still unwell when reported

11 38%

Died

1 3.4%

Euthanised

7 24%

Not known

10 34%

Problems reported at the same time

8 28%

8 28%

7 24%

6 21%

6 21%

Decreased urine concentration

5 17%

Cough

4 14%

Vomiting

4 14%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Trilostane treats Cushing's disease (an overactive adrenal gland).

Products with this ingredient include Vetoryl. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Trilostane cause cardiac disorder in dogs?: 29 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 91 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

All reported side effects of Trilostane in dogs · Medicines most reported with cardiac disorder