Injection site reaction after Tiletamine + Zolazepam in dogs

The FDA has received 39 reports of injection site reaction in dogs after Tiletamine + Zolazepam. That is 2.7% of all reports for this medicine, compared with 1.0% across reports for all dog medicines, so it is reported unusually often with this medicine.

39Reports

62%Marked serious

38%Recovered

7.7%Died or euthanised

1 daysTypical onset

How soon it started

Same day

14 42%

1–2 days

3 9.1%

3–7 days

10 30%

1–4 weeks

2 6.1%

Over a month

4 12%

How the animals did

Recovered

15 38%

Still unwell when reported

7 18%

Euthanised

3 7.7%

Not known

14 36%

Problems reported at the same time

Swelling

13 33%

Didn't work as expected

7 18%

5 13%

5 13%

5 13%

4 10%

Hair loss

4 10%

Lethargy

4 10%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Type: medicine.

Questions owners ask

Can Tiletamine + Zolazepam cause injection site reaction in dogs?: 39 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 1 day of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Injection site reaction with similar medicines

Injection site reaction after Melarsomine (Immiticide) 3,290 reports · 15% of its reports
Injection site reaction after Polysulfated Glycosaminoglycan 263 reports · 4.8% of its reports
Injection site reaction after Diphenhydramine 398 reports · 8.4% of its reports
Injection site reaction after Butorphanol 479 reports · 11% of its reports
Injection site reaction after Cefpodoxime 81 reports · 2.0% of its reports
Injection site reaction after Tramadol 123 reports · 3.3% of its reports
Injection site reaction after Desoxycorticosterone Pivalate 165 reports · 4.9% of its reports
Injection site reaction after Propofol 170 reports · 5.5% of its reports
Injection site reaction after Isoflurane 126 reports · 4.6% of its reports
Injection site reaction after Cephalexin 31 reports · 1.2% of its reports

All reported side effects of Tiletamine + Zolazepam in dogs · Medicines most reported with injection site reaction