Didn't work as expected after Tiletamine + Zolazepam in dogs

499 reports to the FDA describe didn't work as expected in dogs given Tiletamine + Zolazepam. That is 34% of all reports for this medicine, compared with 13% across reports for all dog medicines, so it is reported unusually often with this medicine.

499Reports

35%Marked serious

32%Recovered

25%Died or euthanised

Same dayTypical onset

How soon it started

Same day

245 87%

1–2 days

11 3.9%

3–7 days

6 2.1%

1–4 weeks

9 3.2%

Over a month

10 3.6%

How the animals did

Recovered

158 32%

Still unwell when reported

19 3.8%

Died

16 3.2%

Euthanised

110 22%

Not known

196 39%

Problems reported at the same time

Unrelated death

63 13%

Death

50 10%

Underdose

28 5.6%

Incorrect route of drug administration

20 4.0%

Vocalising

13 2.6%

Restlessness or agitation

11 2.2%

Behaviour change

10 2.0%

Tremors

7 1.4%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Type: medicine.

Questions owners ask

Can Tiletamine + Zolazepam cause didn't work as expected in dogs?: 499 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within the same day of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Didn't work as expected with similar medicines

Didn't work as expected after Melarsomine (Immiticide) 646 reports · 2.8% of its reports
Didn't work as expected after Polysulfated Glycosaminoglycan 698 reports · 13% of its reports
Didn't work as expected after Diphenhydramine 585 reports · 12% of its reports
Didn't work as expected after Butorphanol 1,022 reports · 23% of its reports
Didn't work as expected after Cefpodoxime 671 reports · 17% of its reports
Didn't work as expected after Tramadol 475 reports · 13% of its reports
Didn't work as expected after Florfenicol + Mometasone + Terbinafine 969 reports · 27% of its reports
Didn't work as expected after Desoxycorticosterone Pivalate 355 reports · 11% of its reports
Didn't work as expected after Propofol 600 reports · 20% of its reports
Didn't work as expected after Dirlotapide 712 reports · 25% of its reports

All reported side effects of Tiletamine + Zolazepam in dogs · Medicines most reported with didn't work as expected