Injection site reaction after Isoflurane in dogs

The FDA has received 126 reports of injection site reaction in dogs after Isoflurane. That is 4.6% of all reports for this medicine, compared with 1.0% across reports for all dog medicines, so it is reported unusually often with this medicine.

126Reports

52%Marked serious

26%Recovered

4.0%Died or euthanised

3 daysTypical onset

How soon it started

Same day

25 22%

1–2 days

23 20%

3–7 days

37 32%

1–4 weeks

25 22%

Over a month

4 3.5%

How the animals did

Recovered

31 25%

Recovered with lasting effects

2 1.6%

Still unwell when reported

42 33%

Died

2 1.6%

Euthanised

3 2.4%

Not known

46 37%

Problems reported at the same time

Swelling

46 37%

Loss of appetite

28 22%

Lethargy

27 21%

Application site reaction

15 12%

Hair loss

14 11%

Wound

14 11%

Didn't work as expected

13 10%

Itching

11 8.7%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Type: medicine.

Questions owners ask

Can Isoflurane cause injection site reaction in dogs?: 126 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 3 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Injection site reaction with similar medicines

Injection site reaction after Melarsomine (Immiticide) 3,290 reports · 15% of its reports
Injection site reaction after Polysulfated Glycosaminoglycan 263 reports · 4.8% of its reports
Injection site reaction after Diphenhydramine 398 reports · 8.4% of its reports
Injection site reaction after Butorphanol 479 reports · 11% of its reports
Injection site reaction after Cefpodoxime 81 reports · 2.0% of its reports
Injection site reaction after Tramadol 123 reports · 3.3% of its reports
Injection site reaction after Desoxycorticosterone Pivalate 165 reports · 4.9% of its reports
Injection site reaction after Propofol 170 reports · 5.5% of its reports
Injection site reaction after Cephalexin 31 reports · 1.2% of its reports
Injection site reaction after Atipamezole 225 reports · 8.5% of its reports

All reported side effects of Isoflurane in dogs · Medicines most reported with injection site reaction