Pr-liver, lesion(s) after Selamectin (Revolution) in dogs

39 reports to the FDA describe pr-liver, lesion(s) in dogs given Selamectin. That is 0.1% of all reports for this medicine, compared with 0.3% across reports for all dog medicines, so it is reported less often than average with this medicine.

39Reports
2.6%Marked serious
0.0%Recovered
79%Died or euthanised
–Typical onset
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How the animals did

Still unwell when reported
1 2.6%
Died
30 77%
Euthanised
1 2.6%
Not known
7 18%

Problems reported at the same time

Death
31 79%
Liver problems
21 54%
Vomiting
17 44%
Lethargy
14 36%
Diarrhea
13 33%
Pr-lung(s), lesion(s)
13 33%
Kidney problems
13 33%
Loss of appetite
12 31%

Age of the animals

Under 1 year
11
1–3 years
4
4–7 years
11
8–11 years
6
12+ years
7

About this medicine

Selamectin prevents heartworm and treats fleas, ear mites and some worms (spot-on).

Products with this ingredient include Revolution. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Some herding breeds (for example Collies) carry the MDR1 gene variant and can be more sensitive to this drug class at high doses.

Questions owners ask

Can Selamectin cause pr-liver, lesion(s) in dogs?
39 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Pr-liver, lesion(s) with similar medicines

All reported side effects of Selamectin in dogs · Medicines most reported with pr-liver, lesion(s)