Pr-liver, lesion(s) after Milbemycin Oxime (Interceptor) in dogs

27 reports to the FDA describe pr-liver, lesion(s) in dogs given Milbemycin Oxime. That is 0.1% of all reports for this medicine, compared with 0.3% across reports for all dog medicines, so it is reported less often than average with this medicine.

27Reports
11%Marked serious
3.7%Recovered
56%Died or euthanised
–Typical onset
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How the animals did

Recovered with lasting effects
1 3.7%
Died
14 52%
Euthanised
1 3.7%
Not known
11 41%

Problems reported at the same time

Death
15 56%
Liver problems
15 56%
Vomiting
8 30%
Lethargy
5 19%
Loss of appetite
5 19%
Kidney problems
5 19%
Pr-lung(s), lesion(s)
5 19%
Swelling
4 15%

Age of the animals

Under 1 year
8
1–3 years
4
4–7 years
11
8–11 years
3
12+ years
1

About this medicine

Milbemycin Oxime prevents heartworm and controls some intestinal worms (monthly).

Products with this ingredient include Interceptor. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Some herding breeds (for example Collies) carry the MDR1 gene variant and can be more sensitive to this drug class at high doses.

Questions owners ask

Can Milbemycin Oxime cause pr-liver, lesion(s) in dogs?
27 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Pr-liver, lesion(s) with similar medicines

All reported side effects of Milbemycin Oxime in dogs · Medicines most reported with pr-liver, lesion(s)