Monocytosis after Pyrantel + Sarolaner (Simparica Trio) in dogs
88 reports to the FDA describe monocytosis in dogs given Pyrantel + Sarolaner. That is 0.2% of all reports for this medicine, compared with 0.3% across reports for all dog medicines, so it is reported less often than average with this medicine.
88Reports
86%Marked serious
10%Recovered
14%Died or euthanised
3 daysTypical onset
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How soon it started
How the animals did
Problems reported at the same time
Age of the animals
About this medicine
Pyrantel treats roundworms and hookworms. Sarolaner kills fleas, ticks and some mites; monthly.
Products with this combination include Simparica Trio (which also contains moxidectin). The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.
Questions owners ask
- Can Pyrantel + Sarolaner cause monocytosis in dogs?
- 88 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
- How soon after a dose was it reported?
- In half of the reports with dates, it started within 3 days of the first dose.
- What should I do?
- Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).
Monocytosis with similar medicines
- Monocytosis after Febantel + Praziquantel + Pyrantel (Drontal Plus) 21 reports · 0.3% of its reports
- Monocytosis after Fenbendazole 35 reports · 0.6% of its reports
- Monocytosis after Pyrantel 24 reports · 0.5% of its reports
All reported side effects of Pyrantel + Sarolaner in dogs · Medicines most reported with monocytosis