Pancreatitis after Prednisolone + Trimeprazine in dogs

The FDA has received 24 reports of pancreatitis in dogs after Prednisolone + Trimeprazine. That is 1.1% of all reports for this medicine, compared with 0.4% across reports for all dog medicines, so it is reported unusually often with this medicine.

24Reports

46%Marked serious

13%Recovered

17%Died or euthanised

–Typical onset

How the animals did

Recovered

3 13%

Still unwell when reported

7 29%

Died

2 8.3%

Euthanised

2 8.3%

Not known

10 42%

Problems reported at the same time

14 58%

12 50%

11 46%

9 38%

Elevated lipase

8 33%

Elevated amylase

7 29%

Kidney problems

5 21%

Abnormal radiograph finding

5 21%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Prednisolone reduces inflammation and immune activity.

Steroids commonly cause increased thirst, urination and appetite, especially at higher doses.

Questions owners ask

Can Prednisolone + Trimeprazine cause pancreatitis in dogs?: 24 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Pancreatitis with similar medicines

Pancreatitis after Prednisone 93 reports · 1.0% of its reports
Pancreatitis after Dexamethasone 39 reports · 1.4% of its reports

All reported side effects of Prednisolone + Trimeprazine in dogs · Medicines most reported with pancreatitis