Drooling after Prednisolone + Trimeprazine in dogs

The FDA has received 24 reports of drooling in dogs after Prednisolone + Trimeprazine. That is 1.1% of all reports for this medicine, compared with 1.4% across reports for all dog medicines.

24Reports

42%Marked serious

21%Recovered

25%Died or euthanised

13 daysTypical onset

How soon it started

Same day

1 6.3%

1–2 days

3 19%

3–7 days

1 6.3%

1–4 weeks

5 31%

Over a month

6 38%

How the animals did

Recovered

5 21%

Still unwell when reported

6 25%

Died

5 21%

Euthanised

1 4.2%

Not known

7 29%

Problems reported at the same time

10 42%

8 33%

8 33%

6 25%

6 25%

6 25%

4 17%

4 17%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Prednisolone reduces inflammation and immune activity.

Steroids commonly cause increased thirst, urination and appetite, especially at higher doses.

Questions owners ask

Can Prednisolone + Trimeprazine cause drooling in dogs?: 24 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 13 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Drooling with similar medicines

Drooling after Prednisone 224 reports · 2.5% of its reports
Drooling after Dexamethasone 167 reports · 6.1% of its reports
Drooling after Prednisolone 34 reports · 2.8% of its reports

All reported side effects of Prednisolone + Trimeprazine in dogs · Medicines most reported with drooling