Didn't stop fleas after Praziquantel + Pyrantel in dogs

28 reports to the FDA describe didn't stop fleas in dogs given Praziquantel + Pyrantel. That is 0.8% of all reports for this medicine, compared with 6.2% across reports for all dog medicines, so it is reported less often than average with this medicine.

28Reports

11%Marked serious

11%Recovered

0.0%Died or euthanised

32 daysTypical onset

How soon it started

Same day

2 8.7%

1–2 days

1 4.3%

3–7 days

3 13%

1–4 weeks

4 17%

Over a month

13 57%

How the animals did

Recovered

3 11%

Still unwell when reported

7 25%

Not known

18 64%

Problems reported at the same time

Didn't work as expected

9 32%

Itching

6 21%

Hair loss

4 14%

Skin redness

4 14%

Didn't stop worms

4 14%

Vomiting

3 11%

Skin rash or irritation

3 11%

Restlessness or agitation

3 11%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Praziquantel treats tapeworms. Pyrantel treats roundworms and hookworms.

Questions owners ask

Can Praziquantel + Pyrantel cause didn't stop fleas in dogs?: 28 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 32 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Didn't stop fleas with similar medicines

Didn't stop fleas after Pyrantel + Sarolaner (Simparica Trio) 1,757 reports · 3.3% of its reports
Didn't stop fleas after Fenbendazole 24 reports · 0.4% of its reports
Didn't stop fleas after Pyrantel 25 reports · 0.5% of its reports

All reported side effects of Praziquantel + Pyrantel in dogs · Medicines most reported with didn't stop fleas