Decreased activity after Praziquantel + Pyrantel in dogs

The FDA has received 33 reports of decreased activity in dogs after Praziquantel + Pyrantel. That is 0.9% of all reports for this medicine, compared with 0.2% across reports for all dog medicines, so it is reported unusually often with this medicine.

33Reports

36%Marked serious

21%Recovered

3.0%Died or euthanised

1 daysTypical onset

How soon it started

Same day

12 44%

1–2 days

12 44%

3–7 days

2 7.4%

1–4 weeks

0 0.0%

Over a month

1 3.7%

How the animals did

Recovered

7 21%

Still unwell when reported

1 3.0%

Died

1 3.0%

Not known

24 73%

Problems reported at the same time

16 48%

13 39%

6 18%

6 18%

5 15%

3 9.1%

2 6.1%

Skin rash or irritation

2 6.1%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Praziquantel treats tapeworms. Pyrantel treats roundworms and hookworms.

Questions owners ask

Can Praziquantel + Pyrantel cause decreased activity in dogs?: 33 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 1 day of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Decreased activity with similar medicines

Decreased activity after Pyrantel + Sarolaner (Simparica Trio) 42 reports · 0.1% of its reports

All reported side effects of Praziquantel + Pyrantel in dogs · Medicines most reported with decreased activity