Haemorrhage after Polysulfated Glycosaminoglycan in dogs

The FDA has received 22 reports of haemorrhage in dogs after Polysulfated Glycosaminoglycan. That is 0.4% of all reports for this medicine, compared with 0.1% across reports for all dog medicines, so it is reported unusually often with this medicine.

22Reports

77%Marked serious

14%Recovered

50%Died or euthanised

4 daysTypical onset

How soon it started

Same day

3 23%

1–2 days

3 23%

3–7 days

1 7.7%

1–4 weeks

2 15%

Over a month

4 31%

How the animals did

Recovered

3 14%

Still unwell when reported

2 9.1%

Died

5 23%

Euthanised

6 27%

Not known

6 27%

Problems reported at the same time

10 45%

6 27%

5 23%

4 18%

4 18%

3 14%

Prolonged activated partial thrombin time (aptt)

3 14%

Epistaxis

2 9.1%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Type: medicine.

Questions owners ask

Can Polysulfated Glycosaminoglycan cause haemorrhage in dogs?: 22 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 4 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Haemorrhage with similar medicines

Haemorrhage after Melarsomine (Immiticide) 31 reports · 0.1% of its reports
Haemorrhage after Butorphanol 28 reports · 0.6% of its reports
Haemorrhage after Tramadol 21 reports · 0.6% of its reports
Haemorrhage after Ketoprofen 22 reports · 10% of its reports

All reported side effects of Polysulfated Glycosaminoglycan in dogs · Medicines most reported with haemorrhage