Bone and joint disorder after Polysulfated Glycosaminoglycan in dogs

The FDA has received 54 reports of bone and joint disorder in dogs after Polysulfated Glycosaminoglycan. That is 1.0% of all reports for this medicine, compared with 0.1% across reports for all dog medicines, so it is reported unusually often with this medicine.

54Reports
76%Marked serious
3.7%Recovered
13%Died or euthanised
113 daysTypical onset
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How soon it started

Same day
2 10%
1–2 days
0 0.0%
3–7 days
1 5.0%
1–4 weeks
2 10%
Over a month
15 75%

How the animals did

Recovered
1 1.9%
Recovered with lasting effects
1 1.9%
Still unwell when reported
33 61%
Died
1 1.9%
Euthanised
6 11%
Not known
12 22%

Problems reported at the same time

Age of the animals

Under 1 year
0
1–3 years
2
4–7 years
10
8–11 years
30
12+ years
10

About this medicine

Type: medicine.

Questions owners ask

Can Polysulfated Glycosaminoglycan cause bone and joint disorder in dogs?
54 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 113 days of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Bone and joint disorder with similar medicines

All reported side effects of Polysulfated Glycosaminoglycan in dogs · Medicines most reported with bone and joint disorder