Uncomfortable after Oclacitinib (Apoquel) in dogs

The FDA has received 85 reports of uncomfortable in dogs after Oclacitinib. That is 0.3% of all reports for this medicine, compared with 0.1% across reports for all dog medicines, so it is reported unusually often with this medicine.

85Reports
49%Marked serious
18%Recovered
22%Died or euthanised
11 daysTypical onset
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How soon it started

Same day
12 21%
1–2 days
10 17%
3–7 days
4 6.9%
1–4 weeks
10 17%
Over a month
22 38%

How the animals did

Recovered
15 18%
Still unwell when reported
38 45%
Died
7 8.2%
Euthanised
12 14%
Not known
13 15%

Problems reported at the same time

Lethargy
27 32%
Breathing problems
24 28%
Loss of appetite
22 26%
Death
19 22%
Didn't work as expected
17 20%
Vomiting
15 18%
Restlessness or agitation
15 18%
Diarrhea
14 16%

Age of the animals

Under 1 year
1
1–3 years
11
4–7 years
19
8–11 years
39
12+ years
14

About this medicine

Oclacitinib controls itching from allergies (tablet, a JAK inhibitor).

Products with this ingredient include Apoquel. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Oclacitinib cause uncomfortable in dogs?
85 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 11 days of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Uncomfortable with similar medicines

All reported side effects of Oclacitinib in dogs · Medicines most reported with uncomfortable