Systemic disorder after Oclacitinib (Apoquel) in dogs

77 reports to the FDA describe systemic disorder in dogs given Oclacitinib. That is 0.3% of all reports for this medicine, compared with 0.2% across reports for all dog medicines.

77Reports
44%Marked serious
18%Recovered
25%Died or euthanised
42 daysTypical onset
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How soon it started

Same day
10 19%
1–2 days
3 5.6%
3–7 days
3 5.6%
1–4 weeks
6 11%
Over a month
32 59%

How the animals did

Recovered
14 18%
Still unwell when reported
26 34%
Died
6 7.8%
Euthanised
13 17%
Not known
18 23%

Problems reported at the same time

Age of the animals

Under 1 year
0
1–3 years
8
4–7 years
18
8–11 years
28
12+ years
9

About this medicine

Oclacitinib controls itching from allergies (tablet, a JAK inhibitor).

Products with this ingredient include Apoquel. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Oclacitinib cause systemic disorder in dogs?
77 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 42 days of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Systemic disorder with similar medicines

All reported side effects of Oclacitinib in dogs · Medicines most reported with systemic disorder