High pancreatic-specific lipase after Oclacitinib (Apoquel) in dogs

The FDA has received 59 reports of high pancreatic-specific lipase in dogs after Oclacitinib. That is 0.2% of all reports for this medicine, compared with 0.1% across reports for all dog medicines, so it is reported unusually often with this medicine.

59Reports

68%Marked serious

12%Recovered

14%Died or euthanised

25 daysTypical onset

How soon it started

Same day

1 2.6%

1–2 days

7 18%

3–7 days

2 5.1%

1–4 weeks

12 31%

Over a month

17 44%

How the animals did

Recovered

7 12%

Still unwell when reported

31 53%

Died

2 3.4%

Euthanised

6 10%

Not known

13 22%

Problems reported at the same time

30 51%

29 49%

28 47%

26 44%

16 27%

16 27%

Didn't work as expected

13 22%

Kidney problems

11 19%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Oclacitinib controls itching from allergies (tablet, a JAK inhibitor).

Products with this ingredient include Apoquel. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Oclacitinib cause high pancreatic-specific lipase in dogs?: 59 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 25 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

All reported side effects of Oclacitinib in dogs · Medicines most reported with high pancreatic-specific lipase