Gall bladder & bile duct disorder after Oclacitinib (Apoquel) in dogs

42 reports to the FDA describe gall bladder & bile duct disorder in dogs given Oclacitinib. That is 0.1% of all reports for this medicine, compared with 0.1% across reports for all dog medicines.

42Reports

57%Marked serious

4.8%Recovered

36%Died or euthanised

42 daysTypical onset

How soon it started

Same day

0 0.0%

1–2 days

1 2.9%

3–7 days

2 5.9%

1–4 weeks

11 32%

Over a month

20 59%

How the animals did

Recovered

2 4.8%

Still unwell when reported

24 57%

Died

3 7.1%

Euthanised

12 29%

Not known

1 2.4%

Problems reported at the same time

Liver problems

37 88%

Abnormal ultrasound finding

29 69%

Vomiting

21 50%

Loss of appetite

18 43%

Death

15 36%

Elevated gamma-glutamyl transferase (ggt)

13 31%

Diarrhea

13 31%

Lethargy

11 26%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Oclacitinib controls itching from allergies (tablet, a JAK inhibitor).

Products with this ingredient include Apoquel. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Oclacitinib cause gall bladder & bile duct disorder in dogs?: 42 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 42 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

All reported side effects of Oclacitinib in dogs · Medicines most reported with gall bladder & bile duct disorder