Dehydration after Oclacitinib (Apoquel) in dogs

The FDA has received 182 reports of dehydration in dogs after Oclacitinib. That is 0.6% of all reports for this medicine, compared with 0.7% across reports for all dog medicines.

182Reports

62%Marked serious

13%Recovered

25%Died or euthanised

13 daysTypical onset

How soon it started

Same day

23 18%

1–2 days

18 14%

3–7 days

13 10%

1–4 weeks

23 18%

Over a month

52 40%

How the animals did

Recovered

24 13%

Still unwell when reported

92 51%

Died

16 8.8%

Euthanised

30 16%

Not known

20 11%

Problems reported at the same time

107 59%

106 58%

102 56%

62 34%

57 31%

47 26%

46 25%

28 15%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Oclacitinib controls itching from allergies (tablet, a JAK inhibitor).

Products with this ingredient include Apoquel. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Oclacitinib cause dehydration in dogs?: 182 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 13 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Dehydration with similar medicines

Dehydration after Cyclosporine (Atopica) 131 reports · 0.9% of its reports
Dehydration after Ilunocitinib (Zenrelia) 30 reports · 1.4% of its reports

All reported side effects of Oclacitinib in dogs · Medicines most reported with dehydration