Collapse after Oclacitinib (Apoquel) in dogs

The FDA has received 230 reports of collapse in dogs after Oclacitinib. That is 0.8% of all reports for this medicine, compared with 0.9% across reports for all dog medicines.

230Reports

88%Marked serious

19%Recovered

30%Died or euthanised

24 daysTypical onset

How soon it started

Same day

28 15%

1–2 days

17 9.3%

3–7 days

14 7.7%

1–4 weeks

43 24%

Over a month

80 44%

How the animals did

Recovered

44 19%

Still unwell when reported

91 40%

Died

36 16%

Euthanised

33 14%

Not known

26 11%

Problems reported at the same time

68 30%

58 25%

45 20%

41 18%

40 17%

36 16%

35 15%

34 15%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Oclacitinib controls itching from allergies (tablet, a JAK inhibitor).

Products with this ingredient include Apoquel. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Oclacitinib cause collapse in dogs?: 230 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 24 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Collapse with similar medicines

Collapse after Cyclosporine (Atopica) 179 reports · 1.2% of its reports
Collapse after Ilunocitinib (Zenrelia) 25 reports · 1.1% of its reports

All reported side effects of Oclacitinib in dogs · Medicines most reported with collapse