Collapse after Ilunocitinib (Zenrelia) in dogs

25 reports to the FDA describe collapse in dogs given Ilunocitinib. That is 1.1% of all reports for this medicine, compared with 0.9% across reports for all dog medicines.

25Reports

100%Marked serious

8.0%Recovered

52%Died or euthanised

85 daysTypical onset

How soon it started

Same day

0 0.0%

1–2 days

2 8.3%

3–7 days

2 8.3%

1–4 weeks

6 25%

Over a month

14 58%

How the animals did

Recovered

2 8.0%

Still unwell when reported

4 16%

Died

8 32%

Euthanised

5 20%

Not known

6 24%

Problems reported at the same time

13 52%

9 36%

7 28%

7 28%

Abnormal radiograph finding

5 20%

Abnormal ultrasound finding

4 16%

Cough, hacking

4 16%

Unable to stand

4 16%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Ilunocitinib controls itching from allergies (tablet, a JAK inhibitor).

Products with this ingredient include Zenrelia. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Ilunocitinib cause collapse in dogs?: 25 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 85 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Collapse with similar medicines

Collapse after Oclacitinib (Apoquel) 230 reports · 0.8% of its reports
Collapse after Cyclosporine (Atopica) 179 reports · 1.2% of its reports

All reported side effects of Ilunocitinib in dogs · Medicines most reported with collapse